Abstract
Summary This chapter describes the principal factors and relationships linking the electrophysiology of the brain to cerebral blood flow, viewed mainly from the experimental standpoint and in terms of basic physiological processes of brain function. Topics covered are: the effects of reduced cerebral blood flow on the EEG and on evoked responses recorded at both cortical and subcortical levels, neurotransmitter failure, and conduction failure in white matter; the different flow thresholds associated with electrophysiological failure, related cellular and membrane variables such as cation activities, energy failure and infarction; the recovery of electrophysiological function with restoration of flow following total and partial ischaemia; and the concept of the ischaemic penumbra.
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