Abstract

In a series of 2,316 cases of acute uncomplicated falciparum malaria, there were 50 deaths. Parasites in blood films were counted in all cases daily during treatment. Analysis of this material shows a close relation between the death-rate and the peripheral concentration of parasites at the time treatment began. Parasite counts made at this time were more reliable than clinical judgment as a guide to prognosis, and their routine adoption in all serious falciparum infections is recommended. With few exceptions the presence of falciparum schizonts in blood films at the lower levels of parasitaemia was not a reliable indication of clinical gravity. The vexed question of blood-negative pernicious malaria is briefly discussed. Evidence on the limiting intensity of non-fatal falciparum infection is given.

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