Abstract
In contrast to the inability to demonstrate endotoxin detoxifying activity in either control rat blood, blood cells, plasma, or serum, the induction of mild endotoxemia or trauma resulted in a prompt and marked detoxifying activity in blood plasma or serum, but not in the cellular elements. The functional significance of the blood anti-endotoxin system was demonstrated by a capability for passive transfer and by its loss during severe traumatic shock. A role for the RES in elaboration of the blood anti-endotoxin system is postulated.
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