Blood Dosage of Vitamin D in Pregnant Women and Association with Preeclampsia and Fetal Low Weight

Dias Ba,De Rezende Goston Hsr,Coutinho Lm,Heringer Vccr,Zimmermmann Jb,Batalha Sh,Rodrigues Ys,Panconi Cr,Silva Cs,Fraga Cac,Guerra Pb,De Souza Hd

doi:10.36502/2020/asjbccr.6186

Dias Ba, De Rezende Goston Hsr + Show 10 more

Open Access

https://doi.org/10.36502/2020/asjbccr.6186

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Abstract

Objective: The present study aimed to evaluate the vitamin D blood dosage during the three gestational trimesters, while identifying the frequency of pregnant women in the normal range, the variance in the three periods and evaluate the association between vitamin D and the obstetric complications such as preeclampsia, diabetes, and weight of the newborn. Methods: This is a longitudinal study with pregnant and non-pregnant women, from which there was collected data of anamneses, physical exam, obstetric info, as well as milk consumption habits, sunscreen and sun exposure, and also the vitamin D blood dosage. Results: There were 91 Pregnant Women studied, from whom the comparison between the vitamin D dosages identified the absence of gestation as a protective factor for VDD; the tendency for lower levels of supplementations when the workplace is in an external environment; the association between vitamin D and pre-eclampsia in the first trimester. Conclusion: The most relevant consequences from VDD were pre-eclampsia in the first trimester, the absence of gestation as a protective factor for VDD, and the need to consider the workplace before supplementation.

Highlights

The vitamin D or 25(OH)D is involved in the work mechanics of the musculoskeletal system, in regulating the calcium, phosphor, parathyroid hormone (PTH) and calcitonin metabolism
Vitamin D deficiency was 41,56%, compatible with the described in the literature, and, there is a worldwide consumption with this hypovitaminosis during pregnancy and its influence on the maternal and fetal outcome [11]
Some authors believe that the vitamin D dosage level downsizing during the first trimester is associated with the fetal skeleton formation

Summary

Introduction

The vitamin D or 25(OH)D is involved in the work mechanics of the musculoskeletal system, in regulating the calcium, phosphor, parathyroid hormone (PTH) and calcitonin (thyroid) metabolism. There are two vitamin D sources, one exogenous throw the diet in the form of vitamin D2 (calciferol) and D3 (cholecalciferol) and the other by the endogenous production. The D3 (cholecalciferol), the main vitamin D source is synthesized in the skin by the ultraviolet radiation B (UVB) action by the photolyses of the 7dehydrocholesterol transforming in vitamin D3 [2,3,4]. The main source of vitamin D for children as well as for adults is sunlight exposure, the main VDD cause is the endogenous decreased production. That is why dark-skinned persons have natural protection against the sun, because of the melanin absorbers the UVB radiation, being necessary a solar exposure 3 to 5 times longer to synthesize the same amount of vitamin D as the light-skinned person. The atmospheric contamination and the cloudiness can act as a sunblock, as well as the year station and the time of the day influence the vitamin D cutaneous production [5,6]

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