Abstract
Tissue engineering holds as a prominent technique to repair or replace the damaged human parts to recreate its native function. In this research, a novel scaffold based on polyurethane (PU) comprising megni oil was electrospun for tissue engineering applications. The obtained polyurethane blended with megni oil nanofibers were characterized by scanning electron microscopy (SEM), fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), contact angle measurement and atomic force microscopy (AFM). Furthermore, the blood compatibility of the fabricated nanocomposites evaluated through activated prothrombin time (APTT), partial thromboplastin time (PT) and hemolysis assay to determine the anticoagulant nature. The morphological results showed that the fabricated nanocomposites showed reduced fiber size (789 ± 143.106 nm) than the pristine control (890 ± 116.91 nm). The interaction between PU and megni oil was identified by the hydrogen bond formation evident in the FTIR. The incorporation of megni oil in the PU decreased the wettability behavior (113.3° ± 1.528) and improved the surface roughness (646 nm). Preliminary evaluation of blood compatibility assessments was carried out using APTT, PT and hemolysis assay revealed the enhanced antithrombogenicity nature of the fabricated nanocomposites than the PU. Hence, we conclude that the fabricated new nanocomposite membrane with desirable characteristics which might find potential application in the tissue engineering applications.
Highlights
INTRODUCTIONIt was observed that the addition of metallocene polyethylene and plectranthus amboinicus resulted in the improvement of the blood compatibility and suggested a suitable candidate for bone tissue engineering
In recent days, remodeling/replacement of damaged tissues had been performed using a tissue engineering technique
A novel scaffold comprising PU incorporated with megni oil was fabricated successfully for bone tissue engineering
Summary
It was observed that the addition of metallocene polyethylene and plectranthus amboinicus resulted in the improvement of the blood compatibility and suggested a suitable candidate for bone tissue engineering. From these literatures, it was clearly evident that the electrospun nanofibers with improved blood compatibility serve as a promising component in tissue engineering applications. Polyurethane (PU) finds application in many biomedical devices because of excellent resembling of ECM mainly due to its biodegradable, biocompatibility and good mechanical properties (Lamba et al 1998, Ma et al 2011) Further significant features such as maintaining a moist environment, high swelling ratio and excellent oxidation stability allow the usage of PU in tissue engineering applications (Jaganathan et al 2017a). The objective is to investigate the physicochemical characterizations and blood compatibility assays of the newly developed PU-based nanocomposites to evaluate their effectiveness for tissue engineering
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