Blood coagulation function change and influence factors in Cushing's syndrome and obesity

Abstract

To compare and analysis blood coagulation index change and influence factors in Cushing's syndrome (CS) and obesity (OB) patients to provide theoretical evidence for improving the prognosis of them. A total of 250 patients with CS and 164 patients with obesity were collected from October 2012 to August 2015 in Peking Union Medical College Hospital. Peripheral blood cells, liver and kidney function, blood lipid, 24 h urine free cortisol (24 hUFC) and blood coagulation were tested. The proportion of patients with abnormal blood coagulation indexes were 80% (200/250) and 52% (85/164) respectively in CS and OB patients.Compared with OB patients, coagulation and fibrinolysis values decreased significantly in CS patients. In addition, the shortening of activated partial thromboplastin time (APTT) was more obvious in CS patients, while 24 hUFC, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) were higher than OB. In OB patients, body mass index (BMI), fasting blood-glucose (FBG), TC and LDL-C were associated with blood coagulation abnormalities; in patients with CS, alanine aminotransferase (ALT), aspartate aminotransferase (AST), 24 hUFC, white blood cell (WBC) and platelet (PLT) were associated with blood coagulation abnormalities. Higher coagulation state in CS is likely relevant to higher level of TC, LDL and cortisol hydrocortisone which, in return, have impact on the blood coagulation system, therefore, the risk of thrombosis in CS patients is increased.