Abstract
The effect of benzanthrone (an anthraquinone derivative) on blood coagulation in rats has been investigated. Coagulation time, plasma fibrinogen, platelets, pro-thrombin time, bleeding time and serum calcium have been determined in benzan-throne administered animals at 2, 4, 6, 8, 10, 15 and 30 days. Coagulation time was significantly decreased at 2 days of administration and this decrease remained highly significant upto 10 days. The increase in plasma fibrinogen was highly significant from 2 to 6 days. The number of platelets showed an increase at 2 days which be-came highly significant from 4 to 30 days. Bleeding time was significantly reduced at 10 days. Prothrombin time and serum calcium were unaffected.
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