Blood cancer diagnosis using ensemble learning based on a random subspace method in laser-induced breakdown spectroscopy.

Abstract

There are two main challenges in the diagnosis of blood cancer. The first is to diagnose cancer from healthy control, and the second is to identify the types of blood cancer. The chemometrics method combined with laser-induced breakdown spectroscopy (LIBS) can be used for cancer detection. However, chemometrics methods were easily influenced by the spectral feature redundancy and noise, resulting in low accuracy rate because of their simple structure. We proposed an approach using LIBS combined with the ensemble learning based on the random subspace method (RSM). The serum samples were dripped onto a boric acid substrate for LIBS spectrum collection. The complete blood cancer sample set include leukemia [acute myeloid leukemia (AML) and chronic myelogenous leukemia (CML)], multiple myeloma (MM), and lymphoma. The results showed that the accuracy rates using k nearest neighbors (kNN) and linear discriminant analysis (LDA) only were 88.14% and 94.45%, respectively, while using RSM with LDA (RSM-LDA), the average accuracy rate was improved from 94.45% to 98.34%. Furthermore, the variable importance of spectral lines (Na, K, Mg, Ca, H, O, N, C-N) were evaluated by the RSM-LDA model, which can improve the recognition ability of blood cancer types. Comparing the RSM-LDA model and only with LDA, the results showed that the average accuracy rate for cancer type identification was improved from 80.4% to 91.0%. These results demonstrate that LIBS combined with the RSM-LDA model can discriminate the blood cancer from the health control, as well as the recognition the types for blood cancers.