Abstract
The article provides an overview of the histochemical and molecular mechanisms that regulate the structure and function of the blood-brain barrier (BBB) under conditions of general anesthesia, as well as various physiological and pathological conditions. We analyzed some changes in the process of physiological aging and age-related neurodegenerative disorders. We examined from the position of an anesthesiologist, how the BBB dysfunction is associated with chronic neurological deficit and acute cerebral disorders in stroke, sepsis, traumatic brain injury, spinal cord injury and epilepsy.
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