Abstract
The blood-brain barrier prevents the penetration of neurotoxic components of plasma, blood cells and pathogens into the brain. At the same time, it regulates the transport of molecules in the central nervous system, maintaining a strictly controlled chemical composition of the neuronal environment. This review discusses the molecular and cellular mechanisms that underlie the functioning of the blood-brain barrier, the physiology of the blood-brain barrier transport systems, the structural components of the blood-cerebrospinal fluid barrier and the intrathecal administration of drugs. Based on the physicochemical properties of antibacterial drugs, we estimated which compounds are currently the most promising for the treatment of infections of the central nervous system.
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