Abstract
Choline is an important membrane phospholipid constituent and a neurotransmitter precursor that is minimally synthesized in brain. The long-term maintenance of brain choline concentration is dependent on uptake from plasma, which occurs via saturable transporter at the blood–brain barrier. Previous studies have suggested that brain choline uptake declined with age. To reevaluate this, brain choline uptake in 3, 12, 24, and 28-month-old Fischer-344 rats was evaluated using the in situ brain perfusion technique. Minimal differences were found with uptake parameters differing by ∼10% between aged and adult rats for tracer levels while similar trends were observed at higher choline concentrations. Further, estimated V max and K m values differed by <30% between the groups. The results suggest that blood–brain barrier choline uptake changes minimally with aging in the rat.
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