Blood biomarkers and lifestyle factors in dementia prevention

Abstract

AbstractBackgroundAlzheimer’s disease (AD) is a neurodegenerative disorder with preclinical period that may begin more than 15‐20 years before onset without any clinical symptoms. Risk factors for intervention include obesity in middle age, lack of exercise, hypertension in middle age, diabetes mellitus, smoking, and hearing loss in middle age. Our research indicated that plasma proteins, such as apoA1, transthyretin, and complement C3, may serve as potential biomarkers for mild cognitive impairment (MCI) and Alzheimer’s disease. In this study, we analyzed the associations between risk and protective factors and these plasma protein levels to establish a risk assessment method for dementia.MethodIn present study, we measured blood biomarkers, including apoA1, transthyretin, and complement C3, in 1,736 subjects. We collected medical data from annual health examinations and clinical records of the participants. Additionally, lifestyle questionnaires were incorporated into the research.ResultOur analyses revealed that the risk values in the composite score indicated by the three blood biomarkers were higher in those with a history of dementia and diabetes than in those without a history of dementia and diabetes. The odds ratios (OR) for MCI were 5.27 (CI: 2.14‐13.2) and 1.59 (CI: 1.04‐2.45), respectively. Smoking exhibited a high‐risk value (OR: 1.87, CI: 1.15‐3.01), while smoking cessation led to higher apoA1 levels than in those who continued to smoke. Utilizing the composite score as an index, we analyzed factors that increase or decrease the composite score based on the receipt diagnosis history, health checkup data, and lifestyle questionnaires. We found that the high‐risk group in the composite score was associated with low HDL cholesterol (OR 0.94), high HbA1c (OR 1.6), and right high frequency hearing loss (OR 2.97). Furthermore, we identified several protective factors against MCI, including regular walking and strong physical exercise, drinking 100% fruit and vegetable juices, and avoiding sweetened beverages, and eating sashimi and miso soup.ConclusionOur findings suggest that a firm commitment to lifestyle‐related disease treatment and high‐impact exercise from middle age can help prevent dementia. Additionally, the blood test we used may be useful in presenting specific methods of dementia prevention and evaluating their effectiveness.