Abstract
Alzheimer’s disease (AD), characterized by cognitive decline and devastating neurodegeneration, is the most common age-related dementia. Since AD is a typical example of a complex disease that is affected by various genetic and environmental factors, various factors could be involved in preventing and/or treating AD. Extracellular accumulation of beta-amyloid peptide (Aβ) and intracellular accumulation of tau undeniably play essential roles in the etiology of AD. However, interestingly enough, medications targeting Aβ or tau all failed and the only clinically efficient medications for AD are drugs targeting the cholinergic pathway. Also, a very intriguing discovery in AD is that the Mediterranean diet (MeDi), containing an unusually large quantity of Lactobacilli, is very effective in preventing AD. Based on recently emerging findings, it is our opinion that the reduction of blood ammonia levels by Lactobacilli in MeDi is the therapeutic agent of MeDi for AD. The recent evidence of Lactobacilli lowering blood ammonia level not only provides a link between AD and MeDi but also provides a foundation of pharmabiotics for hyperammonemia as well as various neurological diseases.
Highlights
As the population ages, the incidence and prevalence of age-related diseases have been increasing year by year, posing a new global dilemma
Various epidemiological studies have consistently shown that the Mediterranean diet (MeDi) slow cognitive decline in older adults reduces the risk of mild cognitive impairment, a transitional stage between the cognitive decline of normal aging and most interestingly, lowers the risk of Alzheimer’s disease (AD)
Despite the obvious fact that the MeDi is beneficial for healthy brain, the scientific reason is unclear even
Summary
The incidence and prevalence of age-related diseases have been increasing year by year, posing a new global dilemma. Considering the fact that the gut-brain axis is the most significant signaling between the gastrointestinal (GI) tract and the central nervous system (CNS) in the body, it would not be surprising to note that gut microbiota act as important etiological agents for neurological diseases or modulators for neuronal function. In this context, recent findings of some Lactobacillus strains reducing blood ammonia levels throw a light on how gut microbiota affects neurological diseases and neuronal functions. The fact that certain Lactobacilli strains efficiently reduce blood ammonia levels makes us ponder whether the characteristic of a Mediterranean diet (MeDi), preventing AD roots on the consumption of unusually large quantity of Lactobacilli
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
