Abstract
THE cellular immune response to murine sarcoma virus (MSV)-induced tumours in mice involves lymphoid effector cells of different origins1,2. When the chromium release test (CRT)3–5 is used to study this immune response, only thymus-derived lymphoid cells (T cells) show any appreciable lytic activity towards the appropriate tumour target cells6,7. Other lymphoid cells display no lytic activity in CRT, nor are they required for T cell-dependent tumour cell lysis to occur7. When the micro-cytotoxicity assay (MA) of Takasugi and Klein8 is used to study the cellular immune response of the same MSV tumour-bearing mice, both T and non-T lymphoid cells are seen to be active1,2.
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