Abstract
To the Editor .—I read with interest the recent article in theArchivesby Gengo and colleagues 1 on The effect of β-blockers on mental performance on older hypertensive patients. These findings seem to confirm previous studies by Eisdorfer et al 2-4 and Wilkie et al 5 on learning and autonomic activity. In these studies, Eisdorfer and colleagues 3 determined the extent of heightened and persistent autonomic activation in older men as reflected by elevated levels of free fatty acid. Elderly men evidenced elevated levels of free fatty acid relative to younger men and exhibited a delay in returning to baseline free fatty acid levels when confronted with a learning task. Moreover, cognitive impairment among older men was associated with autonomic hyperarousal 4 and learning
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