Abstract
The γ-aminobutyric acid (GABA) B receptor antagonists 2-OH-saclofen and CGP 35348 were injected in the thalamus of freely moving cats via a microdialysis probe while recording the sleep-waking cycle. The results obtained with the two antagonists were similar: wakefulness and the total sleep time were not affected by the blockade of GABA B receptors, but deep slow wave sleep and the mean power of slow waves (<10 Hz) were decreased, while light slow wave sleep was increased. These data suggest an involvement of thalamic GABA B receptors in the regulation of EEG slow waves.
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