Abstract
Serum and glucocorticoid inducible kinase-1 (SGK-1) is a mechanosensitive kinase implicated in vein bypass graft remodeling and atherogenesis through modulation of metalloproteinase as well as pro-inflammatory cytokine production. More specifically, our laboratory has demonstrated that SGK-1 inhibition in aortic vascular smooth muscle cells downregulated interleukin-6 production, implicating SGK-1 in signaling to accumulate macrophages that can promote degenerative aortic remodeling. It is, therefore, hypothesized that blockade of SGK-1 activity can attenuate AAA growth.
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