Abstract
Viruses use specific host-cell plasma membrane molecules as receptors to enter the cell. SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic, is believed to bind mainly or exclusively to angiotensin-converting enzyme 2 (ACE2), a cell-surface protein otherwise known for its enzymatic, carboxypeptidase-type activity and its physiological role in the renin-angiotensin system.1,2 ACE2 activity per se does not seem to be involved in infectivity, but its role in lung, heart, and kidney function has putative consequences for disease severity.
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