Blockade of Cannabinoid CB1 Receptors in the central amygdala attenuates morphine reward in rats

Abstract

Event Abstract Back to Event Blockade of Cannabinoid CB1 Receptors in the central amygdala attenuates morphine reward in rats Maryam Sardari1*, Ameneh Rezayof1 and Mohammad Reza-Zarrindast2 1 University of Tehran, School of Biology, College of Sciences, Iran 2 Tehran Univ. of Medical Science, Dept. of Pharmacology, School of Medicine, Iran Our previous studies suggest that the central amygdala (CeA) may play an important role in morphine reward. Considering the anatomy and functions of the CeA, it may influence the mesocorticolimbic dopaminergic system that mediates morphine reward. On the other hand, it has been shown that cannabinoids produce some pharmacological effects similar to morphine, because there are functional interactions between the cannabinoid and opioid systems. In the present study, the effects of bilateral injections of a selective cannabinoids receptor (CB1) antagonist, AM251 into the CeA on morphine-induced conditioned place preference (CPP) were investigated in male wistar rats. In these experiments, the animals weighting 220-250g at the time of surgery were used. The animals were cannulated in the CeA by stereotaxic instrument, and were allowed to recover 1- week before training. All procedures were carried out in accordance with institutional guide lines for animal care and use. Using a 3-day schedule of conditioning, it was found that the conditioning treatments with subcuntaneous (s.c) injections of different doses of morphine (0-6 mg/kg) induce a conditional place preference (CPP) in a dose-dependent manner. Intra-CeA administration of AM251 (0-120 ng/rat) inhibited the morphine-induced conditioned place preference. Furthermore, intra-CeA administration of AM251 alone did not induce a significant place preference or place aversion. These findings suggest that the cannabinoid CB1 Receptors of the central amygdala are involved in mediating morphine reward. Conference: 41st European Brain and Behaviour Society Meeting, Rhodes Island, Greece, 13 Sep - 18 Sep, 2009. Presentation Type: Poster Presentation Topic: Poster presentations Citation: Sardari M, Rezayof A and Reza-Zarrindast M (2009). Blockade of Cannabinoid CB1 Receptors in the central amygdala attenuates morphine reward in rats. Conference Abstract: 41st European Brain and Behaviour Society Meeting. doi: 10.3389/conf.neuro.08.2009.09.292 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 15 Jun 2009; Published Online: 15 Jun 2009. * Correspondence: Maryam Sardari, University of Tehran, School of Biology, College of Sciences, Tehran, Iran, Jandark96@yahoo.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Maryam Sardari Ameneh Rezayof Mohammad Reza-Zarrindast Google Maryam Sardari Ameneh Rezayof Mohammad Reza-Zarrindast Google Scholar Maryam Sardari Ameneh Rezayof Mohammad Reza-Zarrindast PubMed Maryam Sardari Ameneh Rezayof Mohammad Reza-Zarrindast Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.