Abstract
Targeted therapy has been the forefront of cancer treatment. Cancer immunotherapy is the most recent focus. In addition, novel immunotherapeutics targeting B cell receptor signaling (e.g., ibrutinib), T cell receptor ( e.g., CART19), and NK cells (e.g., AFM13) are being developed. This review summarized the new development in blinatumomab (MT103/MEDI-538), a first-in-class bispecific T engager (BiTE) antibody against CD19/CD3 in patients with relapsed/refractory precursor B cell acute lymphoid leukemia.
Highlights
Targeted therapy has been the forefront of cancer treatment
This review summarized the clinical development in blinatumomab (MT103/MEDI-538), a first-in-class bispecific T engager (BiTE) antibody against CD19/CD3 in patients with relapsed/refractory precursor B cell acute lymphoid leukemia (ALL)
One obvious disadvantage of this BiTE antibody is the requirement for continuous IV infusion because of the small molecular weight and rapid clearance from circulation
Summary
Targeted therapy has been the forefront of cancer treatment. Cancer immunotherapy is the most recent focus. This review summarized the clinical development in blinatumomab (MT103/MEDI-538), a first-in-class bispecific T engager (BiTE) antibody against CD19/CD3 in patients with relapsed/refractory precursor B cell acute lymphoid leukemia (ALL). Data from animal models support a high activity of blinatumomab at very low doses against tumor cells in lymphoma and leukemia models [43, 48, 55,56,57]. Blinatumomab in clinical development Blinatumomab is the first-in-class BiTE antibody approved for treatment of refractory ALL [46, 47, 58,59,60,61,62,63,64].
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