Abstract
Bleomycin hydrolase (BH), a cysteine protease belonging to the papain superfamily, is one of the candidate β secretases. We performed immunohistochemical studies of Alzheimer's disease (AD) brains using an antibody to BH. Polyclonal antibody to BH immunostained neocortical neurons. The immunoreactivity was also found in senile plaques in AD. These results may suggest a role of BH in amyloid formation.
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