Blends of jackfruit seed starch–pectin in the development of mucoadhesive beads containing metformin HCl

Abstract

In this work, calcium pectinate-jackfruit (Artocarpus heterophyllus Lam.) seed starch (JFSS) mucoadhesive beads containing metformin HCl were developed through ionotropic-gelation. Effects of pectin and JFSS amounts on drug encapsulation efficiency (DEE), and cumulative drug release after 10h (R10h) were optimized using 32 factorial design. The optimized calcium pectinate-JFSS beads containing metformin HCl showed DEE of 94.11±3.92%, R10h of 48.88±2.02%, and mean diameter of 2.06±0.20mm. The in vitro drug release from these beads was followed controlled-release (zero-order) pattern with super case-II transport mechanism. The beads were also characterized by SEM and FTIR. The pH of test mediums was found critical for swelling and mucoadhesion of these beads. The optimized calcium pectinate-JFSS beads also exhibited good mucoadhesivity and significant hypoglycemic effect in alloxan-induced diabetic rats over prolonged period after oral administration.