Abstract
Abstract Electrospinning (ES) is a versatile and diverse technique to fabricate nano and micro fibers that could be utilized as drug delivery systems. The aim of this research was the fabrication and characterization of drug loaded nanofibrous scaffold produced by single-needle ES using poly(Ɛ-caprolactone) (PCL) and poly(ethylene glycol-400) (PEG) and to investigate the potential of this material as a drug delivery system. A model drug, Ibuprofen (IBU), was used. Ibuprofen is a medicine that is a non-steroidal, anti-inflammatory drug (NSAID). Two concentrations of IBU, 5 wt% and 7 wt%, were incorporated for the ES of PCL and PCL/PEG nanofibers. Characterization of nanofibers was done by using Scanning Electron Microscopy (SEM), Differential Scanning Calorimeter (DSC), Thermogravimetric Analysis (TGA), and Water Contact Angle Measurements. The impact of IBU on nanofibers’ properties such as morphology, diameters, hydrophilicity, and tensile strength was investigated. Finally, the drug release kinetics of IBU from nanofibers was analyzed and their percentage release efficiency of IBU (RE%) was determined by UV-vis spectroscopy during 24 h.
Highlights
Wound healing is a complex tissue regeneration process that the human body undergoes to anticipate the affected area with ruptured cellular tissues due to any kind of injury
The ES and characterization of PCL and PCL/poly(ethylene glycol-400) (PEG)-10% nanofibers loaded with IBU were successfully executed
Scanning Electron Microscopy (SEM) analysis determined that nanofibers were round-shaped with heterogeneous morphology of diameters ranging from nano to micro scale
Summary
Wound healing is a complex tissue regeneration process that the human body undergoes to anticipate the affected area with ruptured cellular tissues due to any kind of injury. Inflammation in wounds is another problem that could turn a simple injury into a critical wound, especially in the cases of patients with diabetes or low immunity In such cases, the curing process offers three main challenges: (a) to absorb the sepsis from wound, (b) to relieve the pain, and (c) to protect the wound from the external environment. It is required to change the dressing at regular intervals, preceded by wound cleaning that could be painful and exhausting at times for the patient. Low efficacy of such drug-induced ointments and frequent wound manipulations can often be costly and labor-intensive. The need for an advanced and multifunctional wound dressing is generated, which should exhibit controlled drug delivery and sustainable properties, such as good mechanical strength, hydrophilicity, and biodegradability [2,3,4]
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