Abstract
IntroductionThis study was planned to investigate the impact of severe bleeding and blood transfusion on the development of stroke after coronary surgery. MethodsThis cohort study includes 2357 patients undergoing isolated CABG from the prospective European Coronary Artery Bypass Grafting (E-CABG) registry. Severity of bleeding was categorized according to the Universal Definition of Perioperative Bleeding (UDPB), E-CABG and PLATO definitions. ResultsThirty patients (1.3%) suffered postoperative stroke. The amount of transfused red blood cell (RBC) (OR 1.10, 95%CI 1.03–1.18), preoperative use of unfractioned heparin (OR 4.49, 95%CI 1.91–10.60), emergency operation (OR 3.97, 95%CI 1.47–10.74), diseased ascending aorta (OR 4.62, 95%CI 1.37–15.65) and use of cardiopulmonary bypass (p = 0.043, OR 4.85, 95%CI 1.05–22.36) were independent predictors of postoperative stroke. Adjusted analysis showed that UDPB classes 3–4 (crude rate: 3.6% vs. 1.0%; adjusted OR 2.66, 95%CI 1.05–6.73), E-CABG bleeding grades 2–3 (crudes rate: 6.3% vs. 0.9%; adjusted OR 5.91, 95%CI 2.43–14.36), and PLATO life-threatening bleeding (crude rate: 2.5% vs. 0.6%, adjusted OR 3.70, 95%CI 1.59–8.64) were associated with an increased risk of stroke compared with no or moderate bleeding. ConclusionsBleeding and blood transfusion are associated with an increased risk of stroke after CABG, which is highest in patients with severe bleeding.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.