Abstract
ObjectivesPatients on anticoagulant medications may be at a higher risk of bleeding after acupuncture. This study aimed to assess the association between anticoagulant drug use and bleeding after acupuncture. DesignCase control study SettingWe analysed the diagnosis and treatment records (2000–2018) of a random sample of two million patients from the National Health Insurance Research Database in Taiwan. Interventionsanticoagulant and antiplatelet drugs Main outcome measuresThe incidence rates of major (visceral bleeding or ruptured blood vessels requiring transfusion) and minor (skin bleeding or contusion) bleeding after acupuncture ResultsWe included the records of 13,447,563 acupuncture sessions in 821,946 participants and followed up the patients for 14 days after each session. The incidence of minor bleeding was 8.31 per 10,000 needles, whereas that of major bleeding was 4.26 per 100,000 needles. Anticoagulants significantly increased the risk of minor bleeding (adjusted OR = 1.15 (1.03–1.28)), but the risk of major bleeding did not reach statistical significance (adjusted OR = 1.18 (0.8 0–1.75)). Anticoagulants, such as warfarin (adjusted OR = 4.95 (2.55–7.64)), direct oral anticoagulants (adjusted OR = 3.07 (1.23–5.47)), and heparin (adjusted OR = 3.72 (2.18–6.34)) significantly increased the risk of bleeding. However, antiplatelet drug was not significantly associated with post-acupuncture bleeding. Comorbidities including liver cirrhosis, diabetes, and coagulation defects, were the risk factors for bleeding after acupuncture. ConclusionsAnticoagulant drugs may increase the risk of bleeding after acupuncture. We encourage physicians to ask patients in detail about their medical history and drug use prior to acupuncture treatment.
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