Bleeding gastric metastatic melanoma

Abstract

A 63-year-old man was admitted to AE he had a history of erebral metastases from cutaneous melanoma diagnosed 2 ears before. An urgent upper GI endoscopy was performed hich disclosed multiple typical “bull’s eye” lesions in he gastric corpus, 8–15 mm in diameter: two of these esions appeared ulcerated, covered by a fresh clot, and one ith active blood oozing (Fig. A). Neither other causes of leeding nor other oesophago-gastro-duodenal localizations f melanoma were detected. The bleeding was arrested by combined injective-thermal herapy: epinephrine (1:10,000 dilution) multiple injections t the base of the clots followed by APC treatment; multiple iopsies of a non-bleeding lesion were taken in order to conrm the diagnosis of gastric metastatic melanoma; indeed, he histological specimens showed typical melanoma cells haracterized by round pleiomorphic nuclei with prominent ucleoli and numerous mitotic figures (HE the most common sites of origin are ovary 55%), uterus (7.6%) and melanoma (7%) [2]. Acute bleeding resentation, as in our case, is uncommon and the prognosis oor [3].