Abstract
Chapter 79 discusses bleeding diseases, which result from disruption of the normal blood clotting process. Genetic diseases that cause reduction or dysfunction of clotting factors (hemophilia A and B) and less commonly platelets (von Willebrand disease) are the major bleeding diseases of the musculoskeletal system. The most common bleeding disease of the musculoskeletal system, hemophilia, is caused by deficiency of either factor VIII or factor IX. Hemophilia commonly results in intraarticular hemorrhage resulting in hemophiliac arthropathy and less commonly intramuscular hemorrhage. Imaging of the joints and soft tissues, especially by MRI, is important in disease management.
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