Abstract
Bleached shellac (BS), a biodegradable natural resin purified from insect lac, has been used in a varity of controlled drug delivery systems. Nevertheless, there were negligible researches explored the potential of it as in injectable in situ microparticles (ISM) applications. The goal of this study was to utilize BS to form ISM (shellac-solution dispersed into an external olive oil phase, as o/o emulsion) prepared by two-syringe technique. Addition of glyceryl monostearate (GMS) as stabilizer obviously decreased the emulsion droplet size. ISM emulsion comprising 5% w/w GMS in external phase could form into droplets and precipitate in form of microparticles after exposure to phosphate buffer. 2-Pyrrolidone was the most appropriate solvent to form massive microparticles with regular shape especially at ratio of 7:3 external:internal phases. ISM transformation was occurred after exposure to phosphate buffer and tended to reduce the droplet size when ratio of external phase was higher than 50%. Incorporation of doxycycline hyclate did not influence the amount and size of ISM. Therefore shellac exhibited as an alternative polymer matrix for ISM which higher amount of GMS could reduce the size of emulsion droplet and volume phase ratio seriously influenced on emulsion size and ISM formation.
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