Bladder cancer risk: Use of PLCO and NLST to identify a suitable screening cohort.

Abstract

4546 Background: Bladder cancer (BC) screening is not accepted in part due to low overall incidence. We utilized the PLCO and NLST to identify optimal high-risk populations most likely benefit from screening. Methods: Data were extracted from PLCO and NLST to stratify risk of BC by overall population, gender, race, age at inclusion and smoking status. Incidence rates between groups were compared using chi-square test. Results: BC was identified in 1430/154,898 in PLCO and 439/53,173 in NLST. BCs were grades III/IV in 36.8% and 41.3%, respectively. Incidence rates were significantly higher in men than women (PLCO: 1.4 vs. 0.31/1000 person-years, NLST: 1.84 vs. 0.6/1000 person-years, both p 70 with smoking exposure of 30 pack years (PY) and more, incidence rates were as high as 11.92 (PLCO) and 5.23 (NLST) (per 1000 person-years). In current high int...