Abstract
Bladder cancer and the Notch pathway.
Highlights
Two recent reports, from the group of Dr Klinakis [2] and from us [3], have addressed the role of the Notch pathway in urinary bladder cancer demonstrating that it plays a relevant tumor suppressive role
The transcriptional repressor HES1 is one of the critical transcriptional targets of the Notch pathway, and we showed that reduced HES1 activity upon Notch inhibition is responsible for the de-repression of the EMT program in bladder cancer cells [3]
Mechanistic analyses in culture cells led the authors to conclude that the Notch pathway transcriptionally activates several members of the dualspecificity phosphatases (DUSPs), including DUSP1, by direct binding of the activated NOTCH receptors to their promoter regions [2]
Summary
From the group of Dr Klinakis [2] and from us [3], have addressed the role of the Notch pathway in urinary bladder cancer demonstrating that it plays a relevant tumor suppressive role. The two studies performed mechanistic analyses that shed light on different aspects of the biology of Notch in bladder cancer. The transcriptional repressor HES1 is one of the critical transcriptional targets of the Notch pathway, and we showed that reduced HES1 activity upon Notch inhibition is responsible for the de-repression of the EMT program in bladder cancer cells [3].
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