Abstract
The objectives of this study were to investigate the potential efficacy of black seed oil (BSO) in motor activity, anxiety-like behaviour, cerebellar architecture and Purkinje morphometry in Wistar rats. Saline and black seed oil were administered to adult rats at 1 ml/kg orally for 14 days, and the rats were then subjected to behavioural tests to evaluate locomotor activity and anxiety-like behaviour using the open field and elevated plus mazes paradigms respectively. The cerebella were removed, processed and stained for cerebellar architectonic and Purkinje morphometry respectively. BSO significantly (P ≤ 0.05) increased frequency of line crossing, rearing frequency and total alternation, which are measures of motor activities. It increased open arm explorations, head dip frequency, decreased freezing period and closed arm entry, which are measures of anxiety-like behaviours and did not affect either the architec-tonics of the cerebellar cortices or the Purkinje morphometry when compared with the control. These results suggest that BSO may reduce anxiety related behaviours in Wistar rats.
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