Abstract
In a recent issue of Cancer Cell, Carrot-Zhang et al. identified ancestry-specific molecular variants and expression changes among patients from The Cancer Genome Atlas (TCGA).1 Their study findings and limitations highlight the critical need to diversify populations represented in cancer genomics research.
Highlights
In a recent issue of Cancer Cell, Carrot-Zhang et al identified ancestry-specific molecular variants and expression changes among patients from The Cancer Genome Atlas (TCGA).[1]
Their study findings and limitations highlight the critical need to diversify populations represented in cancer genomics research
Of the major genomic datasets in oncology that offer publicly available ancestry information, The Cancer Genome Atlas (TCGA) includes 83% European ancestry patients compared to 6% each of African and East Asian patients,[2] while the Pan-Cancer Analysis of Whole Genomes (PCAWG) includes 77% European ancestry patients compared to 16% East Asian and 5% African patients.[3]
Summary
In a recent issue of Cancer Cell, Carrot-Zhang et al identified ancestry-specific molecular variants and expression changes among patients from The Cancer Genome Atlas (TCGA).[1]. In a recent issue of Cancer Cell, Carrot-Zhang et al identified ancestry-specific molecular variants and expression changes among patients from The Cancer Genome Atlas (TCGA).[1] Their study findings and limitations highlight the critical need to diversify populations represented in cancer genomics research.
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