BK virus as a predictor of chronic kidney disease in hematopoietic stem cell recipients.

Abstract

7016 Background: Nephropathy from BK virus (BKV) infection is an evolving challenge in hematopoietic stem cell transplantation (HSCT) recipients. In contrast to kidney transplantation, where there are screening protocols for early detection and prevention of symptomatic BKV nephropathy, there is no such guideline in HSCT. We hypothesized that BKV infection is a marker of poor renal outcomes in the HSCT survivor population. Methods: We analyzed all engrafted patients undergoing first allogeneic HSCT at MD Anderson Cancer Center between January 2004 and December 2012, with normal kidney function at the time of HSCT. We evaluated the renal outcome and factors impacting poor renal outcome in these patients. BKV positivity was defined as BKV detection in urine by PCR testing. Renal outcome was determined as the time between HSCT to chronic kidney disease (CKD), defined by constant decrease of 25% or more in estimated glomerular filtration rate (eGFR) compare to the baseline at the time of transplant. Results: ...