Abstract
BK polyomavirus (BKPyV) infection can lead to nephropathy and hemorrhagic cystitis (HC). We evaluated BKPyV genotypes in two individuals after hematopoietic cell transplant (HCT). The first case developed HC and was infected with genotype Ib-2, while the second did not develop HC and was infected with genotype Ia.
Highlights
The reads were mapped to the BK polyomavirus (BKPyV) reference genome sequence Dunlop (GenBank accession number V01108) within UGENE version 36.0, and the resulting consensus sequence was generated from each individual (8)
BKPyV viremia was first noted on day 111 after hematopoietic cell transplant (HCT), but he remained asymptomatic until hemorrhagic cystitis (HC) developed on day 1109
BKPyV was detected on day 128 with viremia of 900 copies per milliliter and viruria of 8.0 Â 109 copies per milliliter
Summary
Human BK polyomavirus (BKPyV) is a circular, double-stranded DNA virus of the Polyomaviridae family (genus Betapolyomavirus) that infects up to 90% of the general population by 10 years of age (1). Received 2 November 2020 Accepted 21 December 2020 Published 14 January 2021 mra.asm.org 1 The reads were mapped to the BKPyV reference genome sequence Dunlop (GenBank accession number V01108) within UGENE version 36.0, and the resulting consensus sequence was generated from each individual (8). For case 2, the genome sequence was 4,657 nucleotides long with a G1C content of 39%.
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