Abstract
BackgroundDespite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of single imaging modality and therapeutic strategy.ResultsHerein, we successfully design and construct BiVO4/Fe3O4@polydopamine (PDA) superparticles (SPs) for computed tomography (CT)/photoacoustic (PA)/magnetic resonance (MR) multimodal imaging and radiotherapy (RT)/photothermal therapy (PTT) synergistic therapy toward oral epithelial carcinoma. On the one hand, BiVO4 NPs endow BiVO4/Fe3O4@PDA SPs with impressive X-ray absorption capability due to the high X-ray attenuation coefficient of Bi, which is beneficial for their utilization as radiosensitizers for CT imaging and RT. On the other hand, Fe3O4 NPs impart BiVO4/Fe3O4@PDA SPs with the superparamagnetic property as a T2-weighted contrast agent for MR imaging. Importantly, the aggregation of Fe3O4 NPs in SPs and the presence of PDA shell greatly improve the photothermal conversion capability of SPs, making BiVO4/Fe3O4@PDA SPs as an ideal photothermal transducer for PA imaging and PTT. By integrating advantages of various imaging modalities (CT/PA/MR) and therapeutic strategies (RT/PTT), our BiVO4/Fe3O4@PDA SPs exhibit the sensitive multimodal imaging feature and superior synergistic therapeutic efficacy on tumors.ConclusionsSince there are many kinds of building blocks with unique properties appropriating for self-assembly, our work may largely enrich the library of nanomateirals for tumor diagnosis and treatment.
Highlights
Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of single imaging modality and therapeutic strategy
BiVO4 NPs are prepared through our previous two-phase method, and Fe3O4 NPs are prepared via the classical thermal decomposition method [34, 35]
Oil-in-water microemulsion method is employed to construct BiVO4/Fe3O4 SPs using BiVO4 and Fe3O4 NPs as the building blocks while sodium dodecyl sulfate (SDS) as the surfactants [36]
Summary
Despite tremendous progress has been achieved in tumor theranostic over the past decade, accurate identification and complete eradication of tumor cells remain a great challenge owing to the limitation of single imaging modality and therapeutic strategy. Republic of China 3 State Key Laboratory of Radiation Medicine and Protection, School cytotoxic reactive oxygen species (ROS) to trigger the apoptosis or necrosis of irradiated cancer cells [6,7,8,9]. The therapeutic efficacy of conventional RT is still limited by the insufficient radiation energy deposition on tumor tissues, as well as the serious toxic effects on normal surrounding healthy tissues [10, 11]. Under NIR light irradiation, photothermal agents generate regional hyperthermia to ablate cancer cells, and promote the blood flow and oxygen pressure levels in tumor tissues, resulting in enhancing the tumor cell sensitivity to RT. It is reasonable to believe that a superior synergistic therapeutic efficacy from RT and PTT will be achieved by taking advantages of radiosensitizers and photothermal agents simultaneously
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
