Biventricular strain analysis at 1.5T cardiac MR imaging: preliminary results in volunteers using an iterative SENSE reconstruction with L1 regularization

Peter M Smith,Mariappan S Nadar,Marius Cordts,Bruce S Spottiswoode,Bradley D Allen,Christoph Guetter,Michael O Zenge,James C Carr,Jeremy D Collins,Marie-Pierre Jolly,Karissa Campione,Michaela Schmidt,Marie Wasielewski,Benjamin H Freed,Maria Carr

doi:10.1186/1532-429x-16-s1-w4

Abstract

Background Changes in myocardial strain have been shown to precede onset of systolic dysfunction in patients with cardiomyopathy. Traditionally performed with echocardiography, acoustic windows can limit strain evaluation. Preliminary work has shown good agreement between myocardial strain derived from deformation field analysis at balanced steady-state free-precession (bSSFP) cine MRI and speckle tracking echocardiography. The application of a novel prototype iterative SENSE reconstruction with L1 regularization (IRSENSE) to highly accelerated segmented bSSFP cine acquisitions can maintain or improve the effective temporal resolution with a shorter breath-hold. The purpose of this study is to evaluate left- and right-ventricular stain analysis from bSSFP cine acquisitions using conventional GRAPPA and highly accelerated T-PAT with IR-SENSE. We hypothesize that myocardial strain parameters derived from accelerated T-PAT cine acquisitions with IR-SENSE are similar to those obtained using conventional segmented bSSFP with comparable effective temporal resolutions.

Highlights

Changes in myocardial strain have been shown to precede onset of systolic dysfunction in patients with cardiomyopathy
Preliminary work has shown good agreement between myocardial strain derived from deformation field analysis at balanced steady-state free-precession cine MRI and speckle tracking echocardiography
The purpose of this study is to evaluate left- and rightventricular stain analysis from balanced steady-state free-precession (bSSFP) cine acquisitions using conventional GRAPPA and highly accelerated T-PAT with IR-SENSE

Summary

Introduction

Changes in myocardial strain have been shown to precede onset of systolic dysfunction in patients with cardiomyopathy. Performed with echocardiography, acoustic windows can limit strain evaluation. Preliminary work has shown good agreement between myocardial strain derived from deformation field analysis at balanced steady-state free-precession (bSSFP) cine MRI and speckle tracking echocardiography. The application of a novel prototype iterative SENSE reconstruction with L1 regularization (IR-SENSE) to highly accelerated segmented bSSFP cine acquisitions can maintain or improve the effective temporal resolution with a shorter breath-hold. The purpose of this study is to evaluate left- and rightventricular stain analysis from bSSFP cine acquisitions using conventional GRAPPA and highly accelerated T-PAT with IR-SENSE. We hypothesize that myocardial strain parameters derived from accelerated T-PAT cine acquisitions with IR-SENSE are similar to those obtained using conventional segmented bSSFP with comparable effective temporal resolutions

Objectives

Methods

Results