Biventricular pacing: Impact on exercise-induced increases in mitral insufficiency in patients with chronic heart failure

Abstract

Mitral regurgitation (MR) in chronic heart failure (CHF) patients frequently worsens with exercise. Cardiac resynchronization therapy (CRT) reduces MR at rest, but its effects on exercise-induced worsening of MR are incompletely explored. The present study examined the influence of CRT on MR during submaximal exercise in CHF patients. Eleven patients with CHF who were treated with CRT underwent echocardiography while performing steady-state exercise during four conduction modes (intrinsic rhythm, right ventricular [RV], biventricular [BiV] and left ventricular [LV] pacing). Measurements of MR were jet area planimetry, effective regurgitant orifice area, peak MR flow rate and regurgitant volume. At rest and during exercise, there were no differences in dyssynchrony between intrinsic rhythm and RV pacing. BiV and LV pacing reduced dyssynchrony at rest and during exercise compared with intrinsic conduction and RV pacing, and there were no differences in the magnitude of these effects between these two pacing modes. At rest, RV pacing increased MR compared with intrinsic conduction (MR regurgitant volume; P<0.05), whereas BiV and LV pacing reduced MR (reductions in effective regurgitant orifice area and jet area; P<0.02, and MR flow rate; P<0.05 with BiV pacing from intrinsic conduction). MR significantly increased on exercise with intrinsic rhythm and RV pacing, whereas with LV and BiV pacing, there were no significant exercise-induced increases in any MR variable. There were relationships between changes in measures of dyssynchrony and reductions in MR at rest and during exercise. CRT reduces MR at rest and during exercise, and prevents exercise-induced MR. Reductions in MR during exercise correlate with improvements in dyssynchrony.