Abstract
Bistachybotrysins W-Y (1–3), three new phenylspirodrimane dimers with a 6/7 oxygen heterocycle as the linkage, were isolated from Stachybotrys chartarum CGMCC 3.5365. The structures of 1–3 were elucidated through extensive spectroscopic data analysis, including 1D/2D NMR, HR-ESI-MS, and ECD spectra. Compounds 1 and 3 displayed moderate cytotoxic activity against human tumor cell lines HCT116, Daoy, and HepG2 with IC50 values ranging from 5.9 to 9.8 μM.
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