Abstract

[35887-81-4] C12H8N2O7S (MW 324.29) InChI = 1S/C12H8N2O7S/c15-13(16)9-1-5-11(6-2-9)20-22(19)21-12-7-3-10(4-8-12)14(17)18/h1-8H InChIKey = GRDMQWRBLJZFML-UHFFFAOYSA-N (preparation of p-nitrophenyl esters for use in peptide synthesis) Physical Data: mp 98–100 °C; bp 172–174 °C/11 mmHg. Solubility: sol MeCN. Preparative Method: by the reaction of p-Nitrophenol with Thionyl Chloride in the presence of Pyridine in benzene at 0 °C.7 Purification: recrystallization from chloroform/hexane. Several recrystallizations are required to obtain the reagent in a pure form. Handling, Storage, and Precautions: may be stored as a solution in acetonitrile at −30 °C; under these conditions, decomposition occurs only slowly. Decomposition and reaction products are p-nitrophenol and sulfur dioxide. Handle with gloves and in a fume hood.

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