Abstract
Bisphosphonates are analogues of pyrophosphate where P-C-P forms the core of molecule in place of P-O-P.They suppress resorption of bone while itself getting absorbed to hydroxyapetite of bone. These are classified into three generations according to modifications in side chain. Bisphosphonates are widely used for osteoporosis, hypercalcemia of malignancy, Paget's disease of bone etc.
Highlights
Bisphosphonates are analogues of pyrophosphate, where PC-P forms the core of molecule in place of P-o-P
Bisphosphonates are widely used for treatment of osteoporosis, Paget’s disease of bone, hypercalcemia of malignancy, prevention and treatment of metastatic cancer of bone
It is an oral bisphosphonate approved by FDA for prevention and treatment of osteoporosis
Summary
Bisphosphonates are analogues of pyrophosphate, where PC-P forms the core of molecule in place of P-o-P. Bisphosphonates are classified according to modification of side chains with differing abilities to inhibit bone resorption. Bisphosphonates are widely used for treatment of osteoporosis, Paget’s disease of bone, hypercalcemia of malignancy, prevention and treatment of metastatic cancer of bone. B. Bisphosphonates especially second and third generation ones have important metabolic effects in mevalonate pathway for isoprenoid lipid synthesis. First generation bisphosphonate administered both intravenously and orally.
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