Abstract
In their well-designed randomized trial, Gong et al. concluded that early initiation of bisphosphonate treatment has no effect on the clinical or radiographic outcomes of distal radial fractures treated with volar plate fixation. Bisphosphonates are currently the most commonly used anti-resorptive medications, and their primary mechanism of action involves inhibition of osteoclastic bone resorption. Because bisphosphonates cause a pronounced suppression of both bone resorption and bone formation, it has been suggested that treatment can interfere with normal fracture-healing. Animal studies, however, have provided controversial evidence1,2, and randomized clinical trials of bisphosphonates have not demonstrated any adverse events associated with fracture-healing. The majority of patients with a distal radial fracture …
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