Abstract
BackgroundTo analyze articles that studied patients submitted to diphosphonates therapy and who received dental implants before, during or after bisphosphonate (BP) treatment, compared to healthy patients, analyzing the increase of failure and loss of implants or bisphosphonate related osteonecrosis of the jaw (BRONJ) incidence.Material and MethodsThe Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) statement was used in this study. The clinical question in “PICO” format was: In patients under bisphosphonate therapy, do dental implants placement, compared to healthy patients, increase the failure and loss of implants or bisphosphonate related osteonecrosis of the jaw incidence? PubMed/MEDLINE was searched for articles published up until April 15, 2015 using a combination of MeSH terms and their Entry terms.ResultsThe search resulted in 375 articles. After selection according to the eligibility criteria, 15 studies fulfilled were included (eight retrospective, one prospective and six case series), with a total of 1339 patients analyzed, 3748 implants placed, 152 loss of implants and 78 cases of BRONJ.ConclusionsDue to the lack of randomized clinical trials looking at this theme, further studies with longer follow-up are needed to elucidate the remaining questions. Thus, it is wise to be careful when planning dental implant surgery in patients undergoing bisphosphonate therapy because of the risk of developing BRONJ as well as occurring failure of implant. Moreover, complete systemic condition of the patient must be also taking into considering when such procedures are performed. Key words:Bisphosphonates, diphosphonates, dental implants, osteonecrosis.
Highlights
Bisphosphonates (BPs) are pyrophosphate analogues with high affinity for the bone hydroxyapatite
The comparison was made with heathy patients who did not were under BP treatment and the outcomes observed were possible failures and loss of implants and the incidence of Bisphosphonate Related Osteonecrosis of the Jaws
After the final evaluation 3 papers were excluded because they did not focus on the relationship between dental implants and bisphosphonate therapy or their sample enrolled much more patient that were not under bisphosphonate treatment than patient under bisphosphonate therapy
Summary
Bisphosphonates (BPs) are pyrophosphate analogues with high affinity for the bone hydroxyapatite. This review aimed to analyze articles that studied patients who were submitted to bisphosphonate therapy and who received dental implants before, during or after the BP treatment. To analyze articles that studied patients submitted to diphosphonates therapy and who received dental implants before, during or after bisphosphonate (BP) treatment, compared to healthy patients, analyzing the increase of failure and loss of implants or bisphosphonate related osteonecrosis of the jaw (BRONJ) incidence. The clinical question in “PICO” format was: In patients under bisphosphonate therapy, do dental implants placement, compared to healthy patients, increase the failure and loss of implants or bisphosphonate related osteonecrosis of the jaw incidence? Complete systemic condition of the patient must be taking into considering when such procedures are performed
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