Bisphosphonate-Related Osteonecrosis of The Jaw (BRONJ) in Neoplastic and Osteoporotic Patients: Statistical Analysis of the Influence of Primary Disease on the Multifocality

Abstract

SYNDROMIC (NBCCS) AND SPORADIC KERATOCYSTIC ODONTOGENIC TUMOUR: DIFFERENT RECURRENCE RATE AFTER CONSERVATIVE SURGERY OF 213 LESIONS Simona Miccoli, Simonetta Franco, Matteo Favia, Maria Grazia Lacaita, Silvio Tafuri, Nicola Laforgia, Gianfranco Favia, Department of Odontostomatology and Surgery, Aldo Moro University, Bari, Italy; Department of Emergency and Organ Transplantation, Aldo Moro University, Bari, Italy; Department of Biomedical Sciences and Human Oncology, Aldo Moro University, Bari, Italy Objective: The purpose of this study is to evaluate the different recurrence rate after conservative surgery in 113 patients with 120 syndromic and 93 sporadic Keratocystic Odontogenic Tumours (KOT) treated between 1979 and 2012 at the University of Bari. Study Design: Conservative surgery consisted of KOT enucleation followed by peripheral ostectomy with rotary or piezoelectric instruments. Chi-Squared-Test (c) was used to find association between recurrence rate and syndromic or sporadic KOT using a 95% significance level (P<0.05). Results: 31 patients were affected by NBCCS (group1) and 82 patients presented sporadic lesions (group2). Out of group1, 12 patients had 26 recurrences (38.71%; n1⁄412/31), whereas out of group2, 8 patients presented 11 recurrences (9.76%; n1⁄48/82); (c1⁄412.95; P1⁄40.0003). Conclusions: Since syndromic patients usually present larger KOT and are more prone to continuous formation of new lesions, recurrence rate is significantly higher in group1; nevertheless recurrence rate in group2 is lower than data reported in literature for the same treatment modality.