Abstract
BackgroundBisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis.Material and Methods38 Wistar rats were injected intraperitoneally with zoledronic acid. After treatment, upper jaw molars were extracted. The animals were randomly assigned to one of two groups. In the control group, saline solution was applied over the alveolar sockets after the tooth extractions. In the treatment group, ASCs were applied instead of saline solution. The control and treatment groups were subdivided based on the time of euthanasia. A clinical and histological analysis was performed.ResultsThe presence of osteonecrosis in alveolar bone was observed in a similar distribution in both groups. In the ASC-treated group, new bone formation was greater than in controls.ConclusionsIn this study, application of ASCs showed greater new bone formation in an osteonecrosis-like murine model. Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of ASCs. Key words:Osteonecrosis; bisphosphonates, Mesenchymal stem cells (MSC), adipose-derived stem cells (ASCs), zoledronic acid.
Highlights
Medication-related osteonecrosis of the jaw (MRONJ) is a painful condition that severely affects quality of life
Previous inhibited post-extraction bone remodelling could be reactivated, and these findings appeared to be secondary to implantation of adipose-derived stem cells (ASC)
The aim of this study was to analyse the potential effect of ASCs in an experimental murine model of BRONJ-like disease induced with zoledronic acid (ZA) after tooth extraction without other enhancer drugs
Summary
Medication-related osteonecrosis of the jaw (MRONJ) is a painful condition that severely affects quality of life. The capacity of ASCs to promote angiogenesis, secrete growth factors, regulate the inflammatory process, and differentiate into multiple cell types makes them a potentially ideal therapy for chronic wounds [12] These properties make ASCs very attractive as a possible tool for prevention of MRONJ. The aim of this study was to analyse the potential effect of ASCs in an experimental murine model of BRONJ (bisphosphonate-related osteonecrosis of the jaw)-like disease induced with zoledronic acid (ZA) after tooth extraction without other enhancer drugs. Bisphosphonate-related osteonecrosis of the jaw is a pathological condition without effective established treatment and preventive strategies. The aim of this study was to analyse the effect of adipose-derived stem cells (ASC) in an experimental murine model of osteonecrosis. In the ASC-treated group, new bone formation was greater than in controls
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