Abstract
This study was designed to identify the effects of bisphosphonate (BP) administration on structure and functions of osteoclasts in alveolar bone resorption during relapse after orthodontic movement of rat molars.Twenty four male rats were used in this study.ToProduce orthodontic force,elastic band was inserted between the upper first and second molars for 21 days. at one day befor elastic band removal, bisphosphonate was administered intraperitoneally. After elastic band removal, the rats were further maintained fpr 0.5 and 10 days. the distal relaose movement of the first molars was examined by means of light, scanning and transmission electron microscopy.In disphosphonate-administred rate, there was adecrease in the distal relapse movement in comparison to the control group and the histological observations revealed reduction in osteoclasts aggregation along the alveolar bone sufaces opposite the pressure side of the periodontal ligament with degenerative structural changes especially at the fifth day. it was concluded that relaps in experimentally moved rat molars through a mechanism involving impairment of the structure and resorptive functions of osteoclasts.
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