Bisphosphonate-associated atypical fracture of the femur: Spontaneous healing with drug holiday and re-appearance after resumed drug therapy with bilateral simultaneous displaced fractures — a case report

Abstract

Our patient is a 64-year-old Chinese woman with a history of asthma with previous prednisolone usage, diabetes mellitus, and breast cancer—for which left simple mastectomy and axillary clearance was performed. Her menopause had been at 54 years and she had been on alendronate for 1 year for osteopenia, diagnosed by bone mineral density scan. She was referred to our department 1 month after her mastectomy for bilateral thigh pain that had lasted 2 weeks, to exclude metastases before commencing chemotherapy. The thighs were tender bilaterally. Plain radiographs of her femurs showed lateral cortex thickening bilaterally with a stress fracture of her right femoral shaft (Figure 1). She had increased uptake at the lower one-third of her right femur and the proximal one-third of her left femur on Tc-99m bone scan. Figure 1. Right (A) and left (C) femur showing lateral cortex thickening. Right femur also showing an undisplaced fracture (B; arrow). In view of the above findings, she was advised to stop alendronate and was wheelchair-mobilized for 6 weeks. The option of intramedullary nailing for the right femur stress fracture and prophylactic nailing of the left femur was discussed with the patient, but on follow-up, there was radiographic evidence of fracture healing (Figure 2). Figure 2. Right femur at 3-month follow-up showing a healing fracture (arrow). Bone mineral density scan at 3 years since stopping alendronate was normal. Repeat Tc-99m bone scan showed reduced uptake of tracer at the right femur compared to the previous bone scan, consistent with a healing fracture. Apart from occasional bilateral thigh pain, our patient was otherwise well. She was converted to letrazole with ibandronic acid by her oncologist at the 5-year follow-up. Once again, she complained of bilateral aching thigh pain on walking and standing, with difficulty climbing stairs. Plain radiographs of her femurs did not reveal any new fractures. She was still ambulating until 7 months after starting ibandronate, when she fell in the toilet after a sudden onset of severe bilateral thigh pain; she was brought to the emergency department with bilateral thigh pain and deformity. Plain radiographs of both her femurs showed bilateral shaft fractures (Figure 3). Blood biochemistry showed a normal serum alkaline phosphatase level, 41 U/L (32–103), and normal total serum calcium, 2.11 mmol/L (2.10–2.60). Her serum Ca 15-3 level, a tumor marker for breast carcinoma, was not elevated either. Figure 3. Fractures of the left and right femurs. Plate fixation of both femoral shafts was performed in a single operation instead of intramedullary nailing with a risk of fat embolism, in view of her history of asthma with baseline hypoxemia (Figure 4). She was wheelchair-mobilized again after surgery and histology from both fracture sites showed fracture hematoma with no evidence of malignancy. The fractures healed uneventfully. Figure 4. After plate fixation.