Abstract
Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers. Regulatory restrictions have been established to prevent risks for human health, leading to BPA substitution by structural analogues, like BPS and BPF. We previously demonstrated that oral perinatal exposure to BPA had long-term consequences on immune responses later in life. It appears now essential to enhance our understanding on immune impact of different routes of BP exposure. In this study, we aimed at comparing the impact of mother dermal exposure to BPs on offspring immune system at adulthood. Gravid mice were dermally exposed to BPA, BPS or BPF at 5 or 50 μg/kg of body weight (BW)/day (d) from gestation day 15 to weaning of pups at post-natal day (PND)21. In offspring, BPs dermal impregnation of mothers led to adverse effects on immune response at intestinal and systemic levels that was dependent on the BP, the dose and offspring sex. These findings provide, for the first time, results on long-term consequences of dermal perinatal BPs exposure on immune responses in offspring. This work warns that it is mandatory to consider immune markers, dose exposure as well as sex in risk assessment associated with new BPA’s alternatives.
Highlights
Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers
Whereas the sex-ratio was quite the same in all groups (Fig. 1A), the BPF5 group was composed by 8 males and only 2 females, causing the withdrawal of BPF5 female offspring group in our study (Supplementary data Fig. 1)
Perinatal exposure to bisphenol F (BPF) at 50 μg/kg BW/d led to a significant decrease of the body weight of male offspring (Fig. 1B)
Summary
Bisphenol (BP)A is an endocrine disruptor (ED) widely used in thermal papers. Regulatory restrictions have been established to prevent risks for human health, leading to BPA substitution by structural analogues, like BPS and BPF. We showed that perinatal exposure to BPA via oral gavage of mothers induced intestinal and systemic immune imbalances in young adult male and female offspring mice, through the modulation of splenic and intestinal Th1/Th17 immune r esponses[25, 26]. These studies highlighted that perinatal BPA exposure via mothers can interfere with the maturing immune system, providing information that warrants major consideration for human safety[27]. The objective of the present study is to compare the effect of mothers’ dermal exposure during gestation and lactation to two doses of BPA, BPS or BPF (5 and 50 μg/kg of BW/d) on immune system at intestinal and systemic levels of male and female offspring mice
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
