Abstract
Frequently occurred food contamination issues bring about a tremendous global demand for point-of-care testing (POCT) devices. Pregnancy test strip (PTS) retains the highest POCT market share and a low cost of $0.10 per test, but challenged by limited analytical sensitivity and non-autonomous signal transduction for drink contaminant monitoring. Herein, we developed a DNA walking machine-assisted commercial PTS method for on-site bisphenol A (BPA) analysis in drink. DNAzyme was operated as the efficient autonomous catalytic walker chain to drive the DNA machine for the amplified signal output of BPA in drink samples. A detection limit of 16.8 pg/mL was obtained, which is three orders of magnitude lower than the regulatory limit of European Union (Commission Regulation (EU) 2020/1245). The POCT strategy constructed in this work has the characteristics of low cost, convenient operation and high analytical sensitivity, represents an attractive option for biosensing and on-site drink safety monitoring.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
