Abstract
Bisphenol A (BPA) is an ubiquitous synthetic chemical exerting numerous adverse effects. Results of rodent studies show that BPA negatively affects adipose tissue. However, the short-term influence of this compound addressing adipocyte metabolism and adipokine secretion is unknown. In the present study, isolated rat adipocytes were exposed for 2 h to 1 and 10 nM BPA. Insulin-induced glucose conversion to lipids along with glucose transport was significantly increased in the presence of BPA. However, basal glucose conversion to lipids, glucose oxidation, and formation of lipids from acetate were unchanged in adipocytes incubated with BPA. It was also shown that BPA significantly increases lipolytic response of adipocytes to epinephrine. However, lipolysis stimulated by dibutyryl-cAMP (a direct activator of protein kinase A) and the antilipolytic action of insulin were not affected by BPA. Moreover, BPA did not influence leptin and adiponectin secretion from adipocytes. Our new results show that BPA is capable of disturbing processes related to lipid accumulation in isolated rat adipocytes. This is associated with the potentiation of insulin and epinephrine action. The effects of BPA appear already after short-term exposure to low doses of this compound. However, BPA fails to change adipokine secretion.
Highlights
Bisphenol A (BPA) is an ubiquitous environmental contaminant
The stimulatory effect was similar in the presence of 1 and 10 nM BPA and reached 12% and 15%, compared with lipogenesis in cells incubated without this compound (Fig. 1b)
Our results have shown that the antilipolytic action of insulin was not significantly altered in adipocytes subjected to BPA action, compared with cells incubated without this compound
Summary
It is thought that human populations worldwide are continuously being exposed to BPA, which largely contributes to numerous health problems. Exposure to BPA is associated, among others, with the risk of Parkinson disease, cancer, cardiovascular diseases, and metabolic disorders (Wade et al 2020). Results of many studies suggest that BPA markedly contributes to the development of type 2 diabetes (Wade et al 2020). Type 2 diabetes is a serious metabolic disease affecting about 5% of people worldwide. This disease is characterized by metabolic abnormalities and impaired insulin secretion and action. It is well established that the risk of type 2 diabetes is markedly increased in the case of adipose tissue
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