Bisphenol A causes mortality and reduced hatching success through increase of cell damage and dysfunction of antioxidant defense system in marine medaka embryo

Abstract

In this study, marine medaka embryos were continuously exposed to different concentrations of bisphenol A (BPA; 200-1000 μg/L) during post fertilization. Mortality, hatching rate, and cellular death in marine medaka embryos were detected. In addition, survival rate of hatched larvae was measured to analyze whether BPA has persistent effects from BPA-exposed embryos to post-hatching period. Our results clearly showed that the hatching rate was decreased in a dose-dependent manner, while the mortality was increased with induction of cellular death and dysfunction of antioxidant defense system in marine medaka embryos. Of hatched larvae, the survival rate was decreased as the exposure concentrations increasing. Thus, our data suggested that early exposure of BPA caused embryonic toxicity, resulted in persistent effects on larval survival in marine medaka.